SPECIFIC INHIBITION BY RIFAMPICIN OF TRANSCRIPTION IN HUMAN LYMPHOCYTES STIMULATED BY PHYTOHEMAGGLUTININ
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چکیده
منابع مشابه
Specific Inhibition by Rifampicin of Transcription in Human Lymphocytes Stimulated by Phytohemagglutinin
Rifampicin, a semisynthetic antibiotic, is known to inhibit the bacterial DNA-dependent RNA polymerase (1), the growth of some animal viruses (2), and the focus formation induced by oncogenic viruses (3, 4). While certain derivatives of rifampicin can inhibit the RNA-dependent DNA polymerase activity of oncogenic viruses, and a similar activity found in normal and virus-transformed cells (5-7),...
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I TARIOUS CLINICAL AND EXPERIMENTAL STUDIES have shown V that chioramphenicol ( CAP) affects cell division. #{176} The characteristic aplastic marrow that is seen when toxicity is fully expressed suggests a toxic effect leading to depletion of dividing cells. The effect of CAP on incorporation of 32 into phytohemagglutinin ( PHA) stimulated lymphocytes was reported by McIntyre and Ebaugh,’ who ...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 1972
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.55.2.515